### The Raw Focus video series is designed to cover the high yield, key concepts around which many examination questions are structured. If you can reproduce these core ideas yourself then the rest of an answer will issue forth.

### The videos will complement content covered in the podcast series and are also posted in the relevant audio section.

### We are working to complete the key concept syllabus listed below. If there are any specific topics that you would like to see covered please get in touch via twitter, or message us at **basicscienceclinic@gmail.com**, and we will produce a personalised video.

**RESPIRATORY**

### 1. Pressure

**1.1 Pressure as potential energy**

**1.2 Units, absolute & gauge pressure**

**1.3 Hydrostatic pressure equation**

### 2. The Gas Laws

**2.1 Ideal, Boyle's, Charles', Guy-Lussac's**

**2.2 Henry's, Dalton's, Avogadro's**

### 3. Humidification

**3.1 Latent heat & specific heat**

**3.4 Absolute humidity & heat loss**

**3.5 Relative/specific humidity & dew point**

### 4. Gas Flow

**4.2 Poiseuille's Law**

**4.3 Viscosity, shear stress & Newtonian fluids**

**4.4 Turbulent flow **

**4.5 Reynold's number & critical velocity**

**4.6 Bernoulli principle & Venturi/Coanda effects**

### 5. Oxygen Cascade

**1.1 Oxygen Cascade**

**1.2 Gas exchange as serial conductances**

### 6. Alveolar Gas Equation

**6.1 Short form AGE**

**6.2 Refined AGE**

### 7. The Ventilation Equation

**7.1 Equation & determinants of PaCO2**

### 8. Airways Resistance

**8.1 Airway generation & resistance**

**8.2 Equal pressure point**

### 9. Elastance & Compliance

**9.1 Lung compliance**

**9.2 Chest wall compliance**

**9.3 Total respiratory system compliance**

**9.4 Elastic recoil & La Place's Law**

### 10. Work of Breathing

**10.1 Calculation & determinants**

**10.2 Optimal work of breathing**

### 11. Lung Volumes

**11.1 Spirometry**

**11.2 Body plethysmography**

**11.3 Functional residual capacity**

**11.4 Closing capacity**

**11.5 Hysteresis**

**11.6 Time constants**

### 12. Diffusion

**12.1 Graham's law**

**12.2 Fick's law**

**12.3 Diffusion & perfusion limitation**

### 13. Dead Space

**13.1 Fowler's method**

**13.2 Bohr equation & Enghoff modification**

### 14. Shunt

**14.1 Shunt equation derivation**

**14.2 Iso-shunt diagram**

### 15. V/Q Ratios

**15.1 Definition & distributions**

**15.2 West's zones**

**15.3 Oxygen-carbon dioxide diagram**

### 16. Minute Ventilation & Gas Partial Pressures

**16.1 MV & oxygen**

**16.2 MV & carbon dioxide**

### 17. Pulmonary Vascular Resistance

**17.1 Calculation & determinants**

**17.2 PVR & lung volume**

### 18. Oxyhaemoglobin Dissociation Curve

**18.1 OHDC**

**18.2 Bohr & Haldane effects**

**18.3 Double Bohr effect**

**18.4 Hamburger shift**

### 19. Carbon Dioxide Carriage

**19.1 Carbon dioxide content curve**

**19.2 Determinants of mixed venous CO2**

**CARDIOVASCULAR**

Cardiac Action Potentials

Wigger's Diagram

Pascal's Law

Bernoulli Principle

Flow, Pressure, Resistance

Preload

Afterload

Contractility

Ventricular PV Loops

Guyton Curves

Valsalva Manoeuvre

Oxygen Flux Equation

Coronary Perfusion

The Right Ventricle

CVP & PCWP

Starling Forces

**PHARMACOLOGY**

Isomers

Functional groups

Compartment models

Half-life

Time constant

Bioavailability

Volume of distribution

Clearance

Michaelis-Menten

Zero order kinetics

Context sensitive half-time

Steady state, loading dose & infusion rate

Placental drug transfer

Occupancy-response coupling

Spare receptor concept

Law of mass action, association/dissociation constants

Affinity, efficacy & potency

Dose response curves

Quantal dose response curves

Agonists (full, partial, inverse)

Antagonists

Summation, potentiation, synergism

Isobologram